Sildenafil citrate
Product name: Sildenafil citrate
Synonym: Viagra
CAS Registry Number: 171599-83-0
M.F.: C28H38N6O11S
M.W.: 666.7
Assays: 99%
Packaging: 1kg/foil bag
Appearance: White fine powder

Price to USA:
Sildenafil citrate (Viagra)(CAS 171599-83-0):
5kg, USD 867;
1KG, USD 261;
500g, USD 165;

Properties: This product is white?or?white crystalline powder, odorless, bitter, astringent insoluble in water and alcohol.

Usage: This product can be made into tablets, capsules, potion of major products such as, adult daily every 50 160mg dosage, dosage according to the situation of the users and increase and decrease, empty stomach (especially to avoid the same service with high lipid food) effect is better, do not use before drinking, tea (users can significantly with stimulus condition effect).

Mechanism of action: Sildenafil can selectively inhibit the activity of PDE5, reduce the degree of cGMP degradation, thus preserving the diastolic cGMP penile function, make the penis erection. Sildenafil also inhibit the ability to some other PDE except PDE5, the selective inhibition of PDE5 is PDE 10 times to thousands of times. Other similar products in the non selective tadalafil inhibition on PDE5 is respectively 5 times and 6 times PDE6, PDE11. Selective inhibition of PDE drugs on the other, is one of the causes of adverse reaction in clinical, compared with other similar products, theoretically, the adverse reaction of sildenafil may be relatively small, but is also found in clinical practice in recent years, it has less adverse reaction of sildenafil.

Pharmacokinetics: after oral administration of sildenafil, almost completely absorbed in the human digestive tract, the peak time (Tmax) in about 1 hours, the average Tmax is 1 hours; the average steady-state volume of distribution (Vd) of 1 to 2 L / kg. Plasma protein binding rate was 84%, the average half-life (T1 / 2) for 3.7 hours, the main drug in liver microsomes by cytochrome P450 enzymes with CYP3A4  role, and ultimately to eliminate non prototype metabolites.

Advantages: with the felling that non comparative and tadalafil, sildenafil pharmacokinetics and reliable and can forecast, the biggest advantage of sildenafil is each patients after taking the drug absorption curve is similar, good repeatability, high reliability, so it is predictable. While cutting the non pharmacokinetics are not predictable, cutting the non strong first pass effect in the liver, due to its low bioavailability (only 14%), pharmacokinetic parameters significant first pass metabolism may lead to the observed subjects own around and between subjects. Considerable variation in each. Tadalafil pharmacokinetic variability also has, the lasting time of 24 ~ 36 hours. Because of the time range is very wide, the drug in patients with different absorption curve will be very different, therefore, each case
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